University of California San Francisco prepared 1/21/2006

CURRICULUM VITAE

Name: John F. Houde

Position: Assistant Adjunct Professor, Step 2

Dept. of Otolaryngology - Head and Neck Surgery

School of Medicine

WOC Researcher

Center for Parkinson's Disease and Movement Disorders

US Dept. of Veteran’s Affairs Medical Center

San Francisco, CA

Address: Room MRIV-126, Box 0444

University of California San Francisco

San Francisco, CA 94143-0444

Voice: (415) 476-2512

FAX: (415) 707-2013

Email: houde@phy.ucsf.edu

www: http://www.keck.ucsf.edu/~houde/

EDUCATION:

1980-85 California Institute of Technology B.S. Electrical Engineering

1988-90 Duke University M.S. Computer Science

1990-97 Massachusetts Institute of Technology Ph.D. Brain and Cog. Sci.

1997-2001 University of California, San Francisco Fellow Medicine

PRINCIPAL POSITIONS HELD:

2001-03 University of California, San Francisco Asst. Research Neuroscientist Medicine

2003-now University of California, San Francisco Asst Adunct Professor Medicine

OTHER POSITIONS HELD CONCURRENTLY:

1991-95 Massachusetts Institute of Technology Teaching Asst. Brain and Cog. Sci.

1996-96 Massachusetts Institute of Technology Teaching Asst. Brain and Cog. Sci.

1997-2001 Scientific Learning Corporation Research Scientist Research

2001-now SF Veterans Affairs Medical Center WOC Researcher Parkinson’s Disease Cen.

HONORS AND AWARDS:

1994 Edward J. Poitras Fellowship, MIT

1994 Angus N. MacDonald Award for Dedication in Teaching, MIT

1998 - 2001 McDonnell-Pew Program in Cognitive Neuroscience 98 Award

KEYWORDS/AREAS OF INTEREST:

Speech, hearing, neuroscience, cognitive science, acoustics, auditory feedback, motor control.

PROFESSIONAL ACTIVITIES

PROFESSIONAL ORGANIZATIONS

Memberships

2001-now Cognitive Neuroscience Society

2001-now Society for Neuroscience

2004-now Association for Research in Otolaryngology

SERVICE TO PROFESSIONAL PUBLICATIONS:

1998-now Ad hoc referee for Journal of Phonetics (1 paper in past 5 years), Journal of Speech, Language, and Hearing Research (4 papers in 5 years), Perception and Psychophysics (1 paper in 5 years), Journal of the Acoustical Society of America (4 papers in 5 years), Nature (2 papers in 5 years), Cerebral Cortex (1 paper in 5 years), Current Biology (1 paper in 5 years), Brain Research (1 paper in 5 years).

INVITED PRESENTATIONS

INTERNATIONAL

5th Seminar on Speech Production: Models and Data, Kloster Seeon, Germany, 2000 (talk)

Linguistics and Phonetics 2002, Meikai University, Tokyo, Japan, 2002 (talk)

Society for Psychophysiological Research 45th Annual Meeting, Lisbon, Portugal, 2005 (talk)

NATIONAL

11th Annual Conference on Neural Information Processing Systems, Denver, CO., 1997 (talk)

REGIONAL AND OTHER INVITED PRESENTATIONS

2004 UCSF OHNS Research Symposium Day (talk)

2004 UCSF Neurology Group (talk)

GOVERNMENT and OTHER PROFESSIONAL SERVICE:

2002 National Institutes of Health NIDCD Ad Hoc Grant Reviewer

2003 National Institutes of Health NIDCD Workshop Participant

2003-04 National Science Foundation Ad Hoc Grant Reviewer

UNIVERSITY AND PUBLIC SERVICE

UNIVERSITY SERVICE

UCSF CAMPUS-WIDE

2002 Electromagnetic Source Imaging system purchase committee, Dept. of Radiology

2002 Functional Imaging Task Force committee, Dept. of Radiology

DEPARTMENTAL SERVICE

2001-2005 Manager, Coleman Journal Club, Dept. of Otolaryngology

TEACHING and MENTORING

POSTGRADUATE AND OTHER COURSES

2002-03 Neurosurgery Residents’ Neuroscience Course, Lecture on speech production, 2 hours

Graduate StuDENTS DIRECTLY SUPERVISED OR MENTORED

Dates	Name	Department	Faculty Role	Current Position
2005-now	Julia Owen	Bioengineering	Research Supervision	Graduate Student, UCB/UCSF

POSTDOCTORAL FELLOWS AND RESIDENTS DIRECTLY SUPERVISED OR MENTORED

Dates	Name	Fellow	Faculty Role	Current Position
2002-now	Theda Heinks-Maldonado Dipl. Psych.	Post-Doc Researcher	Research Supervision	Postdoc, UCSF

OTHER:

2001-2005 Manager, Coleman Journal Club, Dept. of Otolaryngology

TEACHING AWARDS AND NOMNATIONS:

1994 Angus N. MacDonald Award for Dedication in Teaching, MIT

SUMMARY OF TEACHING HOURS:

2002-03: 601 total hours of teaching (including preparation).

Formal class or course teaching hours: 1 hours

Informal teaching hours: 100 hours

Mentoring hours: 500 hours

2003-04 601 total hours of teaching (including preparation).

Formal class or course teaching hours: 1 hours

Informal teaching hours: 100 hours

Mentoring hours: 500 hours

2004-05 Total anticipated hours of teaching: 601 hours (as above).

TEACHING NARRATIVE

Head, Cortical Neurophysiology Seminar, Otolaryngology-Head and Neck Surgery, 150 hours/year

This seminar runs for one hour each Friday afternoon at the Keck Center, and is attended by Professors Steven Cheung, Christoph Schreiner, and Michael Merzenich. Graduate students and postdocs participate in this seminar, where they give talks on their own research or present current journal articles relevant to the seminar's theme: cortical processing and neural plasticity.

Mentor of Graduate Student, Bioengineering Dept., 50 hours/year

My current graduate student is a graduate student from the UCB/UCSF Bioengineering program. I am mentoring her on how to conduct MEG and fMRI studies of speech production.

Mentor of Postdoctoral Trainee, Otolaryngology-Head and Neck Surgery, 50 hours/year

My current postdoctoral fellow is a visiting scholar from Germany. I am mentoring her on how to conduct MEG and fMRI studies of speech production.

RESEARCH AND CREATIVE ACTIVITIES

RESEARCH AWARDS AND GRANTS:

{List grant title and number, your role on the grant (e.g., PI, co-investigator, or consultant), funding period, source of funding, direct costs for year 1, total direct costs for entire period of grant}

CURRENT

BCS-0349582 (PI) 9/1/04-8/31/06

NSF $100,000 direct/yr 1

The Role of Auditory Cortex in Speech Motor Control $150,000 direct/yrs 1-2

R01 DC006435 (Co-PI) 7/1/04-6/31/09

NIH/NIDCD $325,808 direct/yr 1

Neural mechanisms of auditory feedback during speech $1,583,474 direct/yrs 1-5

PENDING

None

PAST

R21 DC05582 (PI) 4/1/02-3/31/05

NIH/NIDCD $125,000 direct/yr 1

The Neural Substrates of Impaired Feedback Control in Parkinsonian Speech $250,000 direct/yrs 1-3

PEER REVIEWED PUBLICATIONS:

1. LeVay, S., Connolly, M., Houde, J., and Van Essen, D. C. The complete pattern of ocular dominance stripes in the striate cortex and visual field of the macaque monkey. J. Neurosci. 5: 486-501, 1985

2. Houde, J.F., and Jordan, M. I. Sensorimotor adaptation in speech production. Science, 279:1213 – 1216, 1998

3. Houde, J.F., and Jordan, M. I. Sensorimotor adaptation of speech I: compensation and adaptation. J. Speech Lang. Hear. Res., 45:295-310, 2002

4. Houde, J.F., Nagarajan, S.S., Sekihara, K., and Merzenich, M.M. Modulation of Auditory Cortex during Speech: An MEG Study. J. Cognitive Neurosci., 14:1125-38, 2002

5. Lakshminarayanan, K., Ben Shalom, D., van Wassenhove, V., Orbelo, D., Houde, J., and Poeppel, D., The effect of spectral manipulations on the identification of affective and linguistic prosody. Brain and Language, 84:250-263, 2003

6. Heinks-Maldonado, T. H. and Houde, J. F. Compensatory responses to brief perturbations of speech amplitude. Acoustics Research Letters Online, 6(3):131-137, 2005

NON-PEER REVIEWED PUBLICATIONS AND OTHER CREATIVE ACTIVITIES:

Other Publications

1. Houde, J.F., Recursive estimation of articulatory control. Computational Cognitive Science Group Technical Report 9101, MIT, Cambridge, MA, 1991

2. Houde, J.F., Adaptation in speech production to transformed auditory feedback. Computational Cognitive Science Group Technical Report 9501, MIT, Cambridge, MA, 1995

3. Houde, J.F., Sensorimotor Adaptation in Speech Production. Doctoral thesis, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, 1997

PATENTS ISSUED

1999 "Feedback Modification for Accent Reduction," United States Patent 5995932

1999 "Feedback Modification for Reducing Stuttering," United States Patent 5940789

ABSTRACTS:

Houde, J.F., and Jordan, M.I. Exploring the functional organization of the speech production system using sensorimotor adaptation. Proceedings of the 2nd Annual meeting of the Cognitive Neuroscience Society, San Francisco, CA, 1995

Houde, J.F., and Jordan, M.I. Adaptation in speech production to transformed auditory feedback. Proceedings of 129th Meeting of the Acoustical Society of America, Washington, DC, 1995

Houde, J.F., Nagarajan, S.S., and Merzenich, M.M. Modulation of auditory cortical magnetic field responses during speech production. Proceedings of the Annual Meeting of the Society for Neuroscience, Miami Beach, FL, 1999

Nagarajan, S.S., Houde, J.F., and Merzenich, M.M. Magnetic field responses of auditory cortex to produced speech. Proceedings of the 138th Meeting of the Acoustical Society of America, Columbus, OH, 1999

Houde, J.F., Nagarajan, S.S., and Merzenich, M.M. What does auditory cortex do when you speak? Proceedings of the Twenty-Third Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, 2000

Houde, J.F., Nagarajan, S.S., and Merzenich, M.M. Suppression of Auditory Cortex during Speech: An MEG Study. Proceedings of the 2000 Meeting of the Cognitive Neuroscience Society, San Francisco, CA, 2000

Nagarajan, S.S., Deutsch, G., Houde, J.F., Szymanski, M., Merzenich, M.M. Plasticity of Auditory Cortical Magnetic Field Responses in Reading-Impaired Children. Proceedings of the Annual Meeting of the Society for Neuroscience, New Orleans, LA, 2000

Caywood, M.S., Blake, D.T.,Houde, J., Merzenich, M.M. Vocalization suppresses neurons in primary auditory cortex of monkey. Proceedings of the Annual Meeting of the Society for Neuroscience, San Diego, CA, 2001

Simmons, D., Houde, J.F., Mori, M., Turner, R.S. Serial reaction time (SRT) learning in macaques: Within session learning, intermanual transfer and perceptual independence. Proceedings of the Annual Meeting of the Society for Neuroscience, Orlando, FL, 2002

Koyama, S., Roberts, T. P. L., Akahane-Yamada, R., Gunji, A., Yabe, H., Kakigi, R., Houde, J. F. Cortical magnetic responses by /r/ and /l/ speech sounds in american english and japanese speakers. Poster presented at the Third International Workshop on Mismatch Negativity and Auditory Functions and Dysfunctions, Lyon, France, May 15-18,2003

Koyama, S., Akahane-Yamada, R., Roberts, T. P. L., Houde, J. F., Merzenich, M. M. Remains of infant days: Cortial magnetic responses from first generation American English speakers. Poster presented at the Joint Meeting of the 27th Annual Meeting of the Japan Neuroscience Society and the 47th Annual Meeting of the Japanese Society for Neurochemistry, Osaka, Japan, 2004

Houde, J. F., Nagarajan, S., Heinks, T., Fox, C., Ramig, L., Marks, W. J., Turner, R. S. The effect of voice therapy on feedback control in Parkinsonian speech. Poster presented at the Movement Disorders 2004 Conference, Rome, Italy, 2004

Nakahara, H., Zhang, L. I., Houde, J. F., Schreiner, C. E., Merzenich, M. M. Changes in primary and secondary auditory cortex by esposure to the phonemes. Poster presented at the Society for Neuroscience 34th Annual Meeting, San Diego, CA, 2004

Houde, J. F., Nagarajan, S. S., Heinks-Maldonado, T. H., Turner, R. S. Magnetic source imaging of feedback perturbations during speaking. Poster presented at the Society for Neuroscience 34th Annual Meeting, San Diego, CA, 2004

Heinks-Maldonado, T. H., Nagarajan, S. S., Halsband, U., Houde, J. F. Specificity of auditory cortex suppression during speech production. Poster presented at the Society for Neuroscience 34th Annual Meeting, San Diego, CA, 2004

Houde, J. F., Nagarajan, S. S., Heinks-Maldonado, T. H. Response of auditory cortex to speech feedback perturbations. Poster presented at the 28th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology, New Orleans, LA,2005

Heinks-Maldonado, T. H., Houde, J. F. Speech responses to perturbations of feedback loudness. Poster presented at the 28th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology, New Orleans, LA,2005

Heinks-Maldonado, T. H., Nagarajan, S. S., Houde, J. F. Magnetic source imaging of feedback perturbations during speaking. Poster presented at the 12th Annual Cognitive Neuroscience Society Meeting, New York, NY, April 9-12,2005

Houde, J. F., Heinks-Maldonado, T., Nagarajan, S. S., Fox, C., Ramig, L., Turner, R. S., Marks, W. J. The neural substrates of impaired feedback processing in Parkinsonian speech. Talk given at Society for Psychophysiological Research 45th Annual Meeting, Lisbon, Portugal, September 20-25, 2005

Nakahara, H., Zhang, L. I., Houde, J. F., Schreiner, C. E., Merzenich, M. M. Development in primary auditory cortex after exposure to phonemes. Poster presented at the Society for Neuroscience 35th Annual Meeting, Washington, DC, 2005

RESEARCH PROGRAM

My role in recent publications:

LeVay, S., Connolly, M., Houde, J., and Van Essen, D. C. The complete pattern of ocular dominance stripes in the striate cortex and visual field of the macaque monkey. J. Neurosci. 5: 486-501, 1985

Created programs to allow unique visualizations of the data presented.

Houde, J.F., and Jordan, M. I. Sensorimotor adaptation in speech production. Science, 279:1213 – 1216, 1998

Originated the research idea, built the apparatus, performed the experiments, wrote the manuscript.

Houde, J.F., and Jordan, M. I. Sensorimotor adaptation of speech I: compensation and adaptation. J. Speech Lang. Hear. Res., 45:295-310, 2002

Originated the research idea, built the apparatus, performed the experiments, wrote the manuscript.

Houde, J.F., Nagarajan, S.S., Sekihara, K., and Merzenich, M.M. Modulation of Auditory Cortex during Speech: An MEG Study. J. Cognitive Neurosci., 14:1125-38, 2002

Originated the research idea, performed the experiments, wrote the manuscript.

Lakshminarayanan, K., Ben Shalom, D., van Wassenhove, V., Orbelo, D., Houde, J., and Poeppel, D., The effect of spectral manipulations on the identification of affective and linguistic prosody. Brain and Language, 84:250-263, 2003

Created the programs to do the required signal processing, performed the signal processing of the test stimuli, wrote corresponding part of methods section of manuscript.

Heinks-Maldonado, T. H. and Houde, J. F. Compensatory responses to brief perturbations of speech amplitude. Acoustics Research Letters Online, 6(3):131-137, 2005

Created the programs to do the required signal processing, supervised writing of manuscript.

Description of current research program:

My research seeks to understand the role of auditory feedback in speech and the neural mechanisms supporting auditory feedback. I currently have projects that examine auditory feedback’s role in the learning and maintenance of speech, as well as the online control of speech.

Auditory Feedback in Learning and Maintenance of Speech

To study the role of auditory feedback in learning and maintenance of speech, I am examining whether speech exhibits long-term adaptation in response to altered auditory feedback. I have found that speakers do adapt their vowel productions to compensate for formant shifts in their acoustic feedback – a result that demonstrates a mechanism enabling speakers to learn and maintain correct speech sound production [see Houde 1998, 1997, 2002 above]. I will continue investigating speech adaptation in the future by seeking an RO1 grant for using functional imaging to study the neural basis of this phenomenon.

Auditory Feedback in Online Control of Speech

To study how auditory feedback is involved in the online control of speech, I am pursuing two approaches. First, I am using magnetoencephalography (MEG) to examine how auditory cortex processes speech feedback, and second, I am investigating how speakers respond to perturbations of their auditory feedback.

How does auditory cortex respond to speech feedback?

My collaborator, Srikantan Nargarajan and I are using magnetoencephalography (MEG) to examine why auditory cortex (A1) responses are suppressed for self-produced speech as compared to externally produced speech. Our results show this is not an overall A1 suppression during speaking. Rather, our results suggest the suppression arises from a comparison between an internal feedback prediction and the actual auditory feedback [see Houde 2000, 2002 above]. We have recently received an NIH RO1 grant (5 years) to pursue these studies.

How do speakers respond to perturbations of their speech feedback?

In my second approach to this issue, I have recently received a grant from NSF to examine the neural substrates of the pitch perturbation reflex (PPR) – a compensatory response to pitch frequency and amplitude feedback perturbations. I am using fMRI to determine areas of the CNS that appear to be involved in the PPR, and subsequently using MEG to determine the order of activation of these areas.

I also currently have an NIH R21 grant to examine the PPR in Parkinson's patients with speech dysfunction. Parkinson's disease results from basal ganglia impairment, and the basal ganglia have been implicated in motor control based on sensory feedback. Thus, in these studies, I hope to (1) determine whether the basal ganglia are an important site of auditory feedback control in speech, and (2) determine the neural substrate of Parkinsonian speech dysfunction.